Helices sculpt membrane
نویسندگان
چکیده
منابع مشابه
Generalization of general helices and slant helices
In this work, we use the formal definition of $k$-slant helix cite{ali2} to obtain the intrinsic equations as well as the position vector for emph{slant-slant helices} which a generalization of emph{general helices} and emph{slant helices}. Also, we present some characterizations theorems for $k$-slant helices and derived, in general form, the intrinsic equations for such curves. Thereafter, fr...
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Dynamin and other proteins of the dynamin superfamily are widely used by cells to sever lipid bilayers. During this process, a short helical dynamin polymer (one to three helical turns) assembles around a membrane tubule and reduces its radius and pitch upon guanosine triphosphate hydrolysis. This deformation is thought to be crucial for dynamin's severing action and results in an observable tw...
متن کاملPrediction of buried helices in multispan alpha helical membrane proteins.
Analysis of a database of structures of membrane proteins shows that membrane proteins composed of 10 or more transmembrane (TM) helices often contain buried helices that are inaccessible to phospholipids. We introduce a method for identifying TM helices that are least phospholipid accessible and for prediction of fully buried TM helices in membrane proteins from sequence information alone. Our...
متن کاملComputational prediction of kink properties of helices in membrane proteins
We have combined molecular dynamics simulations and fold identification procedures to investigate the structure of 696 kinked and 120 unkinked transmembrane (TM) helices in the PDBTM database. Our main aim of this study is to understand the formation of helical kinks by simulating their quasi-equilibrium heating processes, which might be relevant to the prediction of their structural features. ...
متن کاملLong membrane helices and short loops predicted less accurately.
Low-resolution experiments suggest that most membrane helices span over 17-25 residues and that most loops between two helices are longer than 15 residues. Both constraints have been used explicitly in the development of prediction methods. Here, we compared the largest possible sequence-unique data sets from high- and low-resolution experiments. For the high-resolution data, we found that only...
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ژورنال
عنوان ژورنال: Nature
سال: 2005
ISSN: 0028-0836,1476-4687
DOI: 10.1038/4371247a